Faculty of Medicine, Department of Immunology, Allergology and Rheumatology, University Antwerp, Antwerpen, Belgium.
Allergy. 2011 Oct;66(10):1275-86. doi: 10.1111/j.1398-9995.2011.02661.x. Epub 2011 Jun 7.
Adverse drug reactions (ADR) can result from immune-mediated (drug allergy) and nonimmune-mediated mechanisms. In both types of reaction, conclusive diagnosis and appropriate management remain major problems in daily clinical practice. This review summarizes the potentials and shortcomings of the currently available in vitro tests in the diagnosis of immediate (mostly IgE mediated) and nonimmediate (mostly T-cell mediated) drug allergy, particularly quantification of specific IgE, flow-assisted analysis of in vitro activated lymphocytes and basophils and the enzyme-linked immunosorbent spot.
药物不良反应（ADR）可由免疫介导（药物过敏）和非免疫介导机制引起。在这两种反应中，明确的诊断和适当的管理仍然是日常临床实践中的主要问题。本综述总结了目前可用于诊断即刻（主要是 IgE 介导）和非即刻（主要是 T 细胞介导）药物过敏的体外检测的优缺点，特别是特异性 IgE 的定量检测、体外激活淋巴细胞和嗜碱性粒细胞的流式辅助分析以及酶联免疫斑点法。
