Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan.
Intern Med. 2021 May 15;60(10):1573-1576. doi: 10.2169/internalmedicine.6296-20. Epub 2020 Dec 22.
Drug-induced lung injury is defined as a respiratory disorder. The usefulness of the basophil activation test (BAT) for drug allergy-related cases was recently reported. The patient was an 82-year-old woman who had been taking Daisaikoto and Yokukansan (herbal medicines) 3 months before developing dry cough. She was admitted to our hospital with an initial diagnosis of pneumonia with elevated serum LDH, KL-6, and IgE. Chest CT showed bilateral ground-glass opacities. Her bronchoalveolar lavage fluid showed increased eosinophils. Finally, a BAT was positive for both medications. Based on the findings, the patient was diagnosed with Daisaikoto- and Yokukansan-induced lung injury. The current case suggests that the BAT may be useful for the diagnosis of drug-induced lung injury.
药物性肺损伤定义为一种呼吸系统疾病。最近有报道称，嗜碱性粒细胞活化试验（BAT）对与药物过敏相关的病例有用。患者为 82 岁女性，在出现干咳前 3 个月一直在服用大柴胡汤和六君子汤（中药）。她因肺炎、血清 LDH、KL-6 和 IgE 升高而被收入我院。胸部 CT 显示双侧磨玻璃影。其支气管肺泡灌洗液显示嗜酸性粒细胞增多。最终，BAT 对两种药物均呈阳性。根据这些发现，该患者被诊断为大柴胡汤和六君子汤引起的肺损伤。本病例提示 BAT 可能有助于药物性肺损伤的诊断。
