Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.
Clin Exp Allergy. 2011 Oct;41(10):1386-91. doi: 10.1111/j.1365-2222.2011.03789.x. Epub 2011 Jun 6.
Our previous study was the first to demonstrate enhanced plasma IL-6 concentrations in chronic urticaria (CU). It is known that C-reactive protein (CRP) is a sensitive marker of an underlying systemic inflammation, triggered mainly as a response to IL-6.
To evaluate plasma IL-6 concentration in CU patients relating to the clinical disease activity and serum CRP concentration.
Serum CRP and plasma IL-6 concentrations were measured in 58 CU patients and 30 healthy subjects. Ten CU patients were evaluated twice, during the active period as well as upon the spontaneous clinical remission of the disease. CU activity was assessed with the use of the symptom scores recommended by EAACI/GALEN/EDF guidelines.
IL-6 and CRP concentrations were significantly increased in CU patients as compared with the healthy subjects, whereas they decreased remarkably upon the spontaneous remission. IL-6 concentration was associated with weekly urticaria activity scores and also significant differences were found between patients showing different degrees of urticarial activity. Significant correlation was observed between IL-6 and CRP concentrations.
This study reinforces evidence that, apart from a local cutaneous inflammation, CU is associated with a systemic inflammatory response. Such acute-phase response is manifested by increased circulating IL-6, which varies along with CRP changes and may be related to the urticarial activity.
我们之前的研究首次表明，慢性荨麻疹（CU）患者的血浆白细胞介素 6（IL-6）浓度升高。已知 C 反应蛋白（CRP）是潜在全身炎症的敏感标志物，主要作为对 IL-6 的反应而触发。
评估 CU 患者的血浆 IL-6 浓度与临床疾病活动度和血清 CRP 浓度的关系。
测量了 58 例 CU 患者和 30 例健康对照者的血清 CRP 和血浆 IL-6 浓度。10 例 CU 患者在活动期和疾病自发临床缓解时进行了两次评估。使用 EAACI/GALEN/EDF 指南推荐的症状评分来评估 CU 活动度。
与健康对照组相比，CU 患者的 IL-6 和 CRP 浓度显著升高，而在疾病自发缓解时显著降低。IL-6 浓度与每周荨麻疹活动评分相关，且在具有不同程度荨麻疹活动的患者之间也存在显著差异。IL-6 和 CRP 浓度之间存在显著相关性。
这项研究进一步证实了除了局部皮肤炎症外，CU 还与全身炎症反应有关。这种急性期反应表现为循环 IL-6 增加，其变化与 CRP 变化一致，可能与荨麻疹活动度有关。
