Beacham B E, Kurgansky D, Gould W M
Division of Dermatology, University of Maryland Hospital, Baltimore 21201.
J Am Acad Dermatol. 1990 Jun;22(6 Pt 1):1029-32. doi: 10.1016/0190-9622(90)70146-9.
Twenty women had similar symptoms and clinical findings related to the use of tartar control toothpaste. Each had burning and itching around the corners of the mouth, followed by pruritic perioral patches of erythema 4 to 14 days later. All patients had begun using tartar control toothpaste 1 to 2 weeks before onset and had brushed their teeth at least three times per day. The typical findings included a moderately severe perioral erythema with fissuring of the angles of the mouth; scaling erythematous patches, separated by normal skin lateral to the initial erythema, were also present. No vesiculation or crusting was noted, and involvement of the gingiva and buccal mucosa was noted in only one case. On discontinuation of the tartar control toothpaste, marked improvement was seen within 1 to 6 weeks with, in most instances, either no treatment or 1% hydrocortisone cream.
二十名女性出现了与使用防垢牙膏相关的类似症状和临床体征。她们每个人都有嘴角烧灼感和瘙痒感,随后在4至14天后出现口周瘙痒性红斑。所有患者在发病前1至2周开始使用防垢牙膏,并且每天至少刷牙三次。典型表现包括中度严重的口周红斑,口角有皲裂;在初始红斑外侧,还存在被正常皮肤分隔的鳞屑性红斑斑块。未观察到水疱或结痂,仅1例患者出现牙龈和颊黏膜受累。停用防垢牙膏后,在1至6周内可见明显改善,大多数情况下,无需治疗或使用1%氢化可的松乳膏即可。