van Dijken Jan W V, Koistinen S, Ramberg Per
Department of Odontology, Dental School Umeå, Umeå University, 901 87, Umeå, Sweden,
Clin Oral Investig. 2015 Jul;19(6):1507-18. doi: 10.1007/s00784-014-1383-2. Epub 2014 Dec 16.
The aim of this study is to evaluate, in a randomized controlled cross-over study, the effect of daily intake of the alga Ascophyllum nodosum on supragingival calculus, plaque formation, and gingival health over a 6-month period.
Sixty-one adults with moderate to heavy calculus formation since their last yearly recall visit participated. In a randomized order over two 6-month periods, they swallowed two capsules daily, comprising a total of 500 mg dried marine alga powder (Ascophyllum nodosum, ProDen PlaqueOff®) or two negative control tablets. During the study, the participants maintained their regular oral habits. Their teeth were professionally cleaned at the start of each period and after the 6-month registrations. A wash out period of 1 month separated the two 6-month periods. Supragingival calculus (Volpe Manhold), gingivitis (Löe and Silness), gingival bleeding (Ainamo and Bay), and plaque (Quigley-Hein) were registered at screening and at the end of the two periods. Differences in oral health between the test and control periods were analyzed using a paired t test and Wilcoxon signed rank test.
Fifty-five participants completed the study. After the alga intake, the mean calculus reduction was 52% compared to the control (p < 0.0001). Fifty-two participants showed less calculus formation in the alga group than in the control group. Plaque (p = 0.008) and gingival bleeding (p = 0.02) were also significantly less in the alga group. However, no significant difference was found between the groups for gingivitis (p = 0.13).
The alga intake significantly reduced the formation of supragingival calculus and plaque and occurrence of gingival bleeding. The alga has a systemic effect on oral health.
Daily intake of the alga Ascophyllum nodosum as an adjunct to customary oral hygiene showed a major reduction of supragingival calculus formation and reduced plaque formation. In addition, the calculus in the alga group was characterized by a more porous and less solid structure and was easier to remove than the calculus in the control group.
本研究旨在通过一项随机对照交叉研究，评估每日摄入墨角藻对龈上牙石、牙菌斑形成以及牙龈健康在6个月期间的影响。
61名自上次年度复诊以来有中度至重度牙石形成的成年人参与了研究。在两个6个月的时间段内，他们按随机顺序每日吞服两粒胶囊，其中包含总共500毫克干燥海藻粉（墨角藻，ProDen PlaqueOff®）或两片阴性对照片。在研究期间，参与者保持其常规口腔习惯。在每个时间段开始时以及6个月记录期结束后，他们的牙齿接受专业清洁。两个6个月时间段之间有1个月的洗脱期。在筛查时以及两个时间段结束时记录龈上牙石（Volpe Manhold）、牙龈炎（Löe和Silness）、牙龈出血（Ainamo和Bay）以及牙菌斑（Quigley - Hein）。使用配对t检验和Wilcoxon符号秩检验分析试验期和对照期之间口腔健康的差异。
55名参与者完成了研究。摄入海藻后，与对照组相比，牙石平均减少了52%（p < 0.0001）。52名参与者显示海藻组的牙石形成比对照组少。海藻组的牙菌斑（p = 0.008）和牙龈出血（p = 0.02）也显著减少。然而，两组之间在牙龈炎方面未发现显著差异（p = 0.13）。
摄入海藻显著减少了龈上牙石和牙菌斑的形成以及牙龈出血的发生。该海藻对口腔健康有全身作用。
每日摄入墨角藻作为常规口腔卫生的辅助手段，显示龈上牙石形成大幅减少且牙菌斑形成减少。此外，海藻组的牙石具有更多孔且结构更不坚实的特点，比对照组的牙石更容易清除。
