超越氟尿嘧啶：新型化疗药物和靶向药物与放射治疗的新兴作用。

Beyond 5-fluorouracil: the emerging role of newer chemotherapeutics and targeted agents with radiation therapy.

机构信息

Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Semin Radiat Oncol. 2011 Jul;21(3):203-11. doi: 10.1016/j.semradonc.2011.02.006.

DOI:10.1016/j.semradonc.2011.02.006

Abstract

The management of rectal cancer has undergone significant evolution with advances in surgery, radiation therapy, and chemotherapy. These advances have translated into improved rates of local control, survival, and quality of life. More recently, the integration of newer chemotherapeutic and targeted agents in patients with advanced colorectal cancer have led to further improvements in disease-free and overall survival. These agents are now being studied with radiation therapy in the neoadjuvant therapy of rectal cancer.

摘要

直肠癌的治疗在手术、放疗和化疗方面取得了显著进展。这些进展转化为局部控制率、生存率和生活质量的提高。最近，新型化疗药物和靶向药物在晚期结直肠癌患者中的应用进一步改善了无病生存率和总生存率。这些药物目前正在直肠癌新辅助治疗中与放疗联合进行研究。