Cummings B J
Faculty of Medicine, University of Toronto, Ontario, Canada.
Curr Opin Gen Surg. 1994:85-93.
This review outlines the progress made in recently reported trials to establish an effective adjuvant treatment for the surgical management of rectal cancer. Many of the trials of preoperative and postoperative radiation conducted over the past two decades are now mature. Moderate-to-high doses of radiation given prior to or following surgery reduce pelvic tumor recurrence rates but have little effect on survival. The coupling of radiation with cytotoxic chemotherapy, particularly 5-fluorouracil-based protocols, has been reported to improve survival as well as reduce the risk of recurrence in the pelvis and elsewhere. The status of ongoing trials is outlined.
本综述概述了近期报道的旨在为直肠癌手术治疗确立有效辅助治疗方法的试验所取得的进展。过去二十年来进行的许多术前和术后放疗试验现已成熟。手术前或手术后给予中高剂量放疗可降低盆腔肿瘤复发率，但对生存率影响不大。据报道，放疗与细胞毒性化疗联合使用，特别是基于5-氟尿嘧啶的方案，可提高生存率，并降低盆腔及其他部位的复发风险。文中概述了正在进行的试验的情况。
