Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
J Reprod Immunol. 2011 Jun;90(1):91-5. doi: 10.1016/j.jri.2011.03.003. Epub 2011 Jun 8.
A significant proportion of recurrent pregnancy loss (RPL) is associated with immune etiologies. The immunological environment is different between decidua basalis and decidua parietalis, and also different between RPL cases with normal fetal chromosomes and those with abnormal fetal chromosomes. Recent data show that the immune system in a late-stage abortion is completely different from that in an early-stage abortion. If immunocompetent cells can cause RPL, the immunological environment may be a causative factor, especially in an early-stage abortion, and/or at decidua basalis and/or in the cases of RPL with a normal embryo. Careful examination of the immune system at the decidua basalis in an early-stage abortion in RPL cases with normal fetal chromosome may reveal useful information.
相当一部分复发性流产（RPL）与免疫病因有关。蜕膜基底和蜕膜壁的免疫环境不同，染色体正常的 RPL 病例与染色体异常的 RPL 病例的免疫环境也不同。最近的数据表明，晚期流产的免疫系统与早期流产的免疫系统完全不同。如果免疫活性细胞可以导致 RPL，那么免疫环境可能是一个致病因素，尤其是在早期流产中，和/或在蜕膜基底中，和/或在染色体正常的胚胎的 RPL 病例中。仔细检查染色体正常的 RPL 早期流产患者的蜕膜基底中的免疫系统，可能会发现有用的信息。
