一例白塞病患者经泼尼松龙治疗后成功妊娠

Successful Pregnancy in a Case of Behçet's Disease after Treatment with Prednisolone.

作者信息

Nishii Shogo, Yamaguchi Koushi, Amita Mitsuyoshi, Saito Takakazu, Saito Hidekazu, Sekizawa Akihiko

机构信息

Department of Obstetrics and Gynecology, School of Medicine, Showa University, Tokyo 142-8555, Japan.

Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo 157-8535, Japan.

出版信息

Case Rep Obstet Gynecol. 2020 Oct 15;2020:8862651. doi: 10.1155/2020/8862651. eCollection 2020.

DOI:10.1155/2020/8862651

PMID:33123395

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7584932/

Abstract

A 34-year-old woman (gravida 1, para 0) visited the Division of Reproductive Medicine/National Center for Child Health and Development due to infertility; she had also been suffering from incompletely treated genital ulcers and stomatitis for 10 years. This case was diagnosed as an incomplete-type Behçet's disease (BD) at the Department of Maternal-Fetal Biology/National Center for Child Health and Development. Since no apparent abnormality was found in the general infertility test, artificial insemination with the husband's semen (AIH) was performed for the patient with unexplained infertility, which failed. However, after treating BD with prednisolone, chronic inflammation (stomatitis and genital ulcer) and immunological abnormalities (Th2 and NK cell activity) improved, and conception was possible by AIH. Thus, prednisolone administration may have induced immune tolerance in the patient with BD, which may have contributed to the success of AIH.

摘要

一名34岁女性（孕1产0）因不孕就诊于国立儿童健康与发展中心生殖医学科；她还患有未得到彻底治疗的生殖器溃疡和口腔炎达10年之久。该病例在国立儿童健康与发展中心母胎生物学部被诊断为不完全型白塞病（BD）。由于在一般不孕症检查中未发现明显异常，对原因不明的不孕患者实施了丈夫精液人工授精（AIH），但未成功。然而，用泼尼松龙治疗BD后，慢性炎症（口腔炎和生殖器溃疡）和免疫异常（Th2和NK细胞活性）得到改善，通过AIH得以受孕。因此，泼尼松龙给药可能诱导了BD患者的免疫耐受，这可能有助于AIH的成功。