Faculty of Medicine, Institute of Health Sciences, University of Oulu, PO Box 5000, FIN-90014 Oulu, Finland.
Eur J Endocrinol. 2011 Aug;165(2):243-8. doi: 10.1530/EJE-11-0334. Epub 2011 Jun 6.
Ghrelin, a gut-brain peptide involved in energy homeostasis, circulates predominantly (>90%) in unacylated form. Previous studies, however, have focused on total and acylated ghrelin, and the role of unacylated ghrelin (UAG) is not well understood. Particularly, the association of UAG with weight loss and changes in body composition in adults remains unclear. We hypothesized that exercise-associated increase in UAG level is associated with weight loss, favorable changes in body composition, and body fat distribution.
A prospective study of 552 young men (mean age 19.3 and range 19-28 years) undergoing military service with structured 6-month exercise training program. Exercise performance, body composition, and biochemical measurements were obtained at baseline and follow-up. Association between changes in UAG levels and body composition and body fat distribution were evaluated.
An increase in UAG level during the exercise intervention was associated with reduced weight, fat mass (FM), fat percentage (fat %), and waist circumference, but not with fat-free mass. Inverse associations of changes in UAG level with changes in waist circumference and fat % were independent of weight at baseline, and changes in weight and exercise performance. Associations of changes in UAG level with waist circumference were significantly stronger than with fat % after the adjustment for confounding variables.
UAG is associated with changes in body weight and body composition during an intensive long-term exercise intervention in young men. The association of UAG levels with changes in central obesity was stronger than with total FM.
胃饥饿素是一种参与能量稳态的肠脑肽，主要以未酰化形式（>90%）循环。然而，之前的研究集中在总胃饥饿素和酰化胃饥饿素上，未酰化胃饥饿素（UAG）的作用尚不清楚。特别是，UAG 与成年人体重减轻和身体成分变化的关系尚不清楚。我们假设与运动相关的 UAG 水平升高与体重减轻、身体成分的有利变化和体脂分布有关。
对 552 名年轻男性（平均年龄 19.3 岁，范围 19-28 岁）进行前瞻性研究，他们接受了军事服务，并有结构化的 6 个月运动训练计划。在基线和随访时获得运动表现、身体成分和生化测量值。评估 UAG 水平变化与身体成分和体脂分布之间的关系。
运动干预期间 UAG 水平的升高与体重、脂肪量（FM）、脂肪百分比（fat%）和腰围的减少有关，但与去脂体重无关。UAG 水平变化与腰围和脂肪%变化之间的负相关与基线时的体重以及体重和运动表现的变化无关。UAG 水平变化与腰围的相关性在调整混杂变量后明显强于与脂肪%的相关性。
在年轻男性进行强化长期运动干预期间，UAG 与体重和身体成分的变化有关。UAG 水平与中心性肥胖变化的相关性强于与总 FM 的相关性。
