Daniels W M, Jaffer A, Engelbrecht A H, Russell V A, Taljaard J J
Department of Chemical Pathology, University of Stellenbosch, Tygerberg Hospital, Republic of South Africa.
Neurochem Res. 1990 May;15(5):495-9. doi: 10.1007/BF00966206.
The aim of the present study was to investigate whether the hippocampus exerts a modulatory effect on the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Kainic acid was stereotaxically injected into the CA1 pyramidal cell layer of the dorsal hippocampus, causing histological and behavioural changes typical of kainic acid toxicity. The CA3 pyramidal cells of the dorsal hippocampus were selectively lesioned. Rats treated with kainic acid were hyperactive, executed clockwise rotatory movements and displayed epileptic seizures. The acute excitatory effect of kainic acid on glutamatergic receptors in the hippocampus resulted in an elevation in plasma corticosterone levels, suggesting a stimulation of HPA axis activity. Direct or indirect stimulation of the CA1 pyramidal cells of the dorsal hippocampus appeared to have caused the increase in corticosterone secretion.
本研究的目的是调查海马体是否对下丘脑 - 垂体 - 肾上腺（HPA）轴的活动产生调节作用。将 kainic 酸立体定向注射到背侧海马体的 CA1 锥体细胞层，导致出现 kainic 酸毒性典型的组织学和行为变化。背侧海马体的 CA3 锥体细胞被选择性损伤。用 kainic 酸处理的大鼠活动亢进，进行顺时针旋转运动并出现癫痫发作。kainic 酸对海马体中谷氨酸能受体的急性兴奋作用导致血浆皮质酮水平升高，表明 HPA 轴活动受到刺激。对背侧海马体 CA1 锥体细胞的直接或间接刺激似乎导致了皮质酮分泌增加。
