Medical University Innsbruck, Innsbruck, Austria.
Rheumatol Int. 2012 Jun;32(6):1815-8. doi: 10.1007/s00296-011-1973-0. Epub 2011 Jun 7.
The complement system plays a role in the pathogenesis of some autoimmunopathies. This longitudinal study evaluates the contribution of the complement system in the pathogenesis of oligoarticular juvenile idiopathic arthritis (JIA). Serum of the peripheral blood and the synovial fluid were investigated for the activity of the classical (CP), the mannose binding lectin (MBL), and the alternative pathway (AP). A total of 12 samples from peripheral blood (PB) and two samples from synovial fluid (SF) of girls with oligoarticular JIA were investigated in a longitudinal observation from the time point of the diagnosis of JIA. The differences between the complement activity in the PB and in the SF were extremely statistically significant (CP and MBL: P < 0.0001; AP: < 0.0087). The activity of the CP and the MBL pathway was reduced. The AP is the main contributor in the pathogenesis of oligoarticular JIA. Anti-C5 therapy may be an option to avoid the creation of the membrane attack complex.
补体系统在某些自身免疫性疾病的发病机制中起作用。这项纵向研究评估了补体系统在寡关节型幼年特发性关节炎（JIA）发病机制中的作用。研究了外周血血清和滑液中经典途径（CP）、甘露糖结合凝集素（MBL）和替代途径（AP）的活性。对 12 名寡关节型 JIA 女孩的外周血（PB）和 2 份滑液（SF）样本进行了纵向观察，从 JIA 诊断时间点开始。PB 和 SF 中的补体活性差异具有统计学意义（CP 和 MBL：P < 0.0001；AP：< 0.0087）。CP 和 MBL 途径的活性降低。AP 是寡关节型 JIA 发病机制的主要贡献者。抗 C5 治疗可能是避免形成膜攻击复合物的一种选择。
