Seelen Marc A J, Roos Anja, Daha Mohamed R
Department of Nephrology, Leiden University Medical Center, Leiden - The Netherlands.
J Nephrol. 2005 Nov-Dec;18(6):642-53.
The complement system is a major driver of our innate immune response and plays an important role in defence against foreign pathogens. It is composed of a large number of proteins that are found in the circulation, in tissues and other body fluids in pro-enzymatic form. The many biologic activities of the complement system are uncovered following activation by three known pathways. Together with phagocytic cells the complement system is a powerful tool to defend the host against foreign attack. However the complement system, under certain conditions, can be unfavorable to the host namely in diseases such as IgA nephropathy, systemic lupus erythematosus and in diseases where minor changes have occurred in the integrity of tissue such as in ischemia reperfusion. This review describes the many faces of complement in the field of innate and acquired immunity and takes the reader on a journey of the role of complement in health and disease.
补体系统是我们先天免疫反应的主要驱动因素，在抵御外来病原体方面发挥着重要作用。它由大量以酶原形式存在于循环系统、组织和其他体液中的蛋白质组成。补体系统的多种生物学活性在通过三种已知途径激活后得以显现。补体系统与吞噬细胞一起，是宿主抵御外来攻击的有力工具。然而，在某些情况下，补体系统可能对宿主不利，即在诸如IgA肾病、系统性红斑狼疮等疾病中，以及在组织完整性发生微小变化的疾病中，如缺血再灌注损伤。这篇综述描述了补体系统在先天免疫和获得性免疫领域的多面性，并带领读者了解补体系统在健康和疾病中的作用。
