日本脑炎病毒感染中铁水平的变化。

Mathur A, Bharadwaj M, Chaturvedi U C

Postgraduate Department of Microbiology, K.G. Medical College, Lucknow, India.

J Exp Pathol (Oxford). 1990 Jun;71(3):307-12.

Following Japanese encephalitis virus (JEV) infection in mice the serum iron concentration decreased; the decline started from day 3 and persisted up to day 9 postinfection. No significant difference was found in the total iron-binding capacity of serum in JEV-infected mice compared with that of controls. The hypoferraemia was associated with accumulation of iron in the spleen. Large amounts of stainable iron were demonstrated in splenic macrophages from day 5. This was accompanied by transient anaemia. Thus, the hypoferraemia, following intraperitoneal inoculation of JEV, was attributed to a block in the release of iron from the RES.

小鼠感染日本脑炎病毒（JEV）后，血清铁浓度降低；这种下降从感染后第3天开始，一直持续到感染后第9天。与对照组相比，JEV感染小鼠血清的总铁结合能力没有显著差异。低铁血症与脾脏中铁的积累有关。从第5天起，脾脏巨噬细胞中出现大量可染色铁。这伴随着短暂的贫血。因此，腹腔接种JEV后的低铁血症归因于网状内皮系统（RES）铁释放受阻。