Chaturvedi U C, Mathur A, Tandon P, Natu S M, Rajvanshi S, Tandon H O
Clin Exp Immunol. 1979 Dec;38(3):492-8.
The peripheral blood leucocytes of twenty-four cases of Japanese encephalitis (JE) were studied and the findings were compared with those in twenty-five normal health controls of matching age and sex. In the early phases of the disease marked neutrophil leucocytosis was seen which returned to almost normal levels by the fourth week. Lymphopenia was associated with diminished T lymphocytes but the number of B lymphocytes remained within the normal range. Though the number of T lymphocytes was reduced, their function of leucocyte migration inhibition in the presence of JE virus antigen was significantly higher. The phagocytic activity of the neutrophils, as shown by the uptake of neutral red dye, was diminished but the phagocytic activity of monocytes as shown by the uptake of neutral red dye, was diminished but the phagocytic activity of monocytes as shown by the uptake of neutral red dye or ingestion of latex particles remained unaffected. HI antibodies against JE virus were significantly higher in cases of encephalitis as compared with the control group. Thus, JE virus infection in man has a variable effect on different components of the peripheral blood leucocytes.
对24例日本脑炎（乙脑）患者的外周血白细胞进行了研究，并将研究结果与25名年龄和性别相匹配的正常健康对照者进行了比较。在疾病早期可见明显的中性粒细胞增多，到第四周时几乎恢复到正常水平。淋巴细胞减少与T淋巴细胞数量减少有关，但B淋巴细胞数量仍在正常范围内。虽然T淋巴细胞数量减少，但其在乙脑病毒抗原存在下的白细胞迁移抑制功能明显更高。中性粒细胞摄取中性红染料所显示的吞噬活性降低，但单核细胞摄取中性红染料或吞噬乳胶颗粒所显示的吞噬活性未受影响。与对照组相比，脑炎患者针对乙脑病毒的血凝抑制（HI）抗体明显更高。因此，人类感染乙脑病毒对外周血白细胞的不同成分有不同影响。
