Jin Wu, Cheng Fa-Xiang, Xiao Mei-Sun, Fan Yang, Dong Wang
Department of Pediatrics, Second Hospital of West China, Sichuan University, Chengdu, China.
J Pediatr Endocrinol Metab. 2011;24(3-4):237-9. doi: 10.1515/jpem.2011.082.
Concurrent deficiencies of three hormones in patients with Turner's syndrome (TS) have rarely been reported. Here, we describe a case of a young girl who had Turner's syndrome with concomitant chronic lymphocytic thyroiditis, growth hormone deficiency, and hypothyroidism with cardiopericarditis.
An 11-year-old girl was referred to the outpatient clinic because of short stature, ochriasis, and cardiopalmus. Her ultrasound revealed absence of ovarian tissue. Karyotype examination suggested Turner's syndrome with sex hormone deficiency. She was found to have an abnormal thyroid gland and elevated thyroid stimulating hormone (TSH). A positive thyroid autoantibody titer confirmed the diagnosis of chronic lymphocytic thyroiditis with hypothyroidism. Furthermore, her growth hormone levels were well below normal.
A multi-endocrine disorder, i.e., Turner's syndrome with chronic lymphocytic thyroiditis, growth hormone deficiency, and hypothyroidism with cardiopericarditis was diagnosed. Growth hormone and thyroxin substitution therapy was suggested.
特纳综合征（TS）患者同时存在三种激素缺乏的情况鲜有报道。在此，我们描述一例患有特纳综合征并伴有慢性淋巴细胞性甲状腺炎、生长激素缺乏以及甲状腺功能减退合并心包炎的年轻女孩病例。
一名11岁女孩因身材矮小、面色发黄和心悸被转诊至门诊。她的超声检查显示卵巢组织缺失。核型检查提示特纳综合征伴性激素缺乏。她被发现甲状腺异常且促甲状腺激素（TSH）升高。甲状腺自身抗体滴度呈阳性，确诊为慢性淋巴细胞性甲状腺炎合并甲状腺功能减退。此外，她的生长激素水平远低于正常范围。
诊断为多内分泌腺疾病，即特纳综合征合并慢性淋巴细胞性甲状腺炎、生长激素缺乏以及甲状腺功能减退合并心包炎。建议进行生长激素和甲状腺素替代治疗。
