Lecornu M, Treussard I, Jezequel C
Service de Pédiatrie A, Hôpital Sud, Rennes.
Arch Fr Pediatr. 1988 Jun-Jul;45(6):411-2.
Two patients with Turner's syndrome and Hashimoto's thyroiditis are described. The incidence of the karyotype 46 XX (iq), 45 X is high in this association reported in the literature; thus, 17 patients among 25 with Turner's syndrome and thyroiditis had a structural abnormality of the X chromosome. Routine thyroid antibodies determination should be carried out in patients with gonadal dysgenesis between 10 and 20 years of age, and early replacement therapy should be undertaken in Turner's syndrome with Hashimoto's thyroiditis, since clinical signs of hypothyroidism are usually delayed.
本文描述了两名患有特纳综合征和桥本甲状腺炎的患者。文献报道,在这种关联中,核型为46 XX(嵌合体)、45 X的发生率很高;因此,25名患有特纳综合征和甲状腺炎的患者中有17名存在X染色体结构异常。对于10至20岁的性腺发育不全患者,应常规检测甲状腺抗体,对于患有桥本甲状腺炎的特纳综合征患者,应尽早进行替代治疗,因为甲状腺功能减退的临床症状通常出现较晚。