Jacquemier J, Kurtz J M, Amalric R, Brandone H, Ayme Y, Spitalier J M
Department of Anatomic Pathology, Marseille Cancer Institute, France.
Br J Cancer. 1990 Jun;61(6):873-6. doi: 10.1038/bjc.1990.195.
The influence of extensive intraductal component (EIC) on local recurrence risk was studied for 496 patients with stage I-II infiltrating ductal cancers treated by conservative surgery and irradiation. EIC was diagnosed in 65 of 231 (28%) premenopausal and 41 of 265 (15.5%) post-menopausal patients. Local recurrence risk was markedly increased in EIC+ patients (5-year actuarial risk 18% versus 8% without EIC, P less than 0.001), but this effect appeared limited to premenopausal patients. Local recurrence risk increased with increasing degree of EIC. EIC with more than 50% intraductal carcinoma was more prevalent in patients younger than 40, perhaps accounting to some degree for the higher local recurrence rates observed in younger patients. The presence of EIC had no influence on overall survival, on median time to local recurrence, or on short-term survival after local failure. The usefulness of EIC as a risk factor for local recurrence is discussed.
对496例接受保乳手术和放疗的Ⅰ-Ⅱ期浸润性导管癌患者，研究了广泛导管内成分（EIC）对局部复发风险的影响。231例绝经前患者中有65例（28%）诊断为EIC，265例绝经后患者中有41例（15.5%）诊断为EIC。EIC阳性患者的局部复发风险显著增加（5年精算风险为18%，无EIC者为8%，P<0.001），但这种影响似乎仅限于绝经前患者。局部复发风险随EIC程度的增加而增加。导管内癌超过50%的EIC在40岁以下患者中更为常见，这在一定程度上可能是年轻患者局部复发率较高的原因。EIC的存在对总生存率、局部复发的中位时间或局部复发后的短期生存率均无影响。本文讨论了EIC作为局部复发风险因素的实用性。
