State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
Org Lett. 2011 Jul 1;13(13):3510-3. doi: 10.1021/ol2013268. Epub 2011 Jun 7.
A novel chiral Perazamacrocyclic fluorescent sensor (1) was designed and synthesized. It can serve as a fluorescent turn-off sensor with high selectivity toward Cu(II) among 14 metal ions. Furthermore, though 1 exhibits no enantioselectivity, after adding Cu(II), the in situ generated Cu(II)-containing complex of 1 (Cu(II)-1) can exhibit remarkable fluorescent enhancement responses and considerable enantioselectivities toward unmodified α-amino acids in protic solutions via a ligand displacement mechanism; i.e. a cascade recognition of Cu(II) and unmodified α-amino acids has been achieved.
设计并合成了一种新型手性 Perazamacrocyclic 荧光传感器（1）。它可以作为一种荧光关闭传感器，在 14 种金属离子中对 Cu(II)具有高选择性。此外，尽管 1 不具有对映选择性，但加入 Cu(II)后，1 原位生成的 Cu(II)配合物（Cu(II)-1）可以通过配体取代机制在质子溶液中对未修饰的α-氨基酸表现出显著的荧光增强响应和相当大的对映选择性；即实现了对 Cu(II)和未修饰的α-氨基酸的级联识别。
