Ivanova N L, Leĭkina M I, Sokolova N A
Fiziol Zh SSSR Im I M Sechenova. 1990 Mar;76(3):351-6.
Opioid peptides exert ino- and chronotropic effects on the heart. Paraopioid dermorphine (Y-dA-F-G-Y-P-S) was earlier shown to act as negative inotropic agent in isolated frog's hearts. In this study, the same effect was investigated in cultured myocardiac cells of the newborn rats. Dermorphine (10(-4)-10(-9) M) dose-dependently attenuated the contraction amplitude with the latency of 5-10 min. The peak of the response appeared in 30-45 min after application of dermorphine. The mu-opiate-receptor antagonist naloxone (10(-5) g/ml) blocked this effect. Dermorphine seems to exert its negative inotropic action through the opiate receptors, presumably of the mu-subtype.
阿片肽对心脏有变力性和变时性作用。前期研究表明，类阿片物质皮肤吗啡（Y-dA-F-G-Y-P-S）在离体蛙心中作为负性变力剂起作用。在本研究中，在新生大鼠的培养心肌细胞中研究了同样的作用。皮肤吗啡（10⁻⁴ - 10⁻⁹ M）剂量依赖性地减弱收缩幅度，潜伏期为5 - 10分钟。应用皮肤吗啡后30 - 45分钟出现反应峰值。μ-阿片受体拮抗剂纳洛酮（10⁻⁵ g/ml）可阻断此作用。皮肤吗啡似乎通过阿片受体发挥其负性变力作用，推测为μ亚型。
