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[乳酸菌产生的细菌素]

[Bacteriocins produced by lactic acid bacteria].

作者信息

Bilková Andrea, Sepova Hana Kinová, Bilka Frantisek, Balázová Andrea

机构信息

Univerzita Komenského v Bratislave, Farmaceutická fakulta, Katedra bunkovej a molekulmárnej biológie lieciv, Slovenská republika.

出版信息

Ceska Slov Farm. 2011 Apr;60(2):65-72.

Abstract

Lactic acid bacteria comprise several genera of gram-positive bacteria that are known for the production of structurally different antimicrobial substances. Among them, bacteriocins are nowadays in the centre of scientific interest. Bacteriocins, proteinaceous antimicrobial substances, are produced ribosomally and have usually a narrow spectrum of bacterial growth inhibition. According to their structure and the target of their activity, they are divided into four classes, although there are some suggestions for a renewed classification. The most interesting and usable class are lantibiotics. They comprise the most widely commercially used and well examined bacteriocin, nisin. The non-pathogenic character of lactic acid bacteria is advantageous for using their bacteriocins in food preservation as well as in feed supplements or in veterinary medicine.

摘要

乳酸菌包括几个革兰氏阳性菌属,它们以产生结构不同的抗菌物质而闻名。其中,细菌素如今是科学研究的热点。细菌素是蛋白质类抗菌物质,通过核糖体合成,通常具有较窄的细菌生长抑制谱。根据其结构和作用靶点,它们被分为四类,不过也有一些关于重新分类的建议。最有趣且实用的一类是羊毛硫抗生素。它们包含商业上应用最广泛且研究充分的细菌素——乳酸链球菌素。乳酸菌的非致病性有利于将其细菌素用于食品保鲜、饲料添加剂或兽医学领域。

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