单纯疱疹病毒2型38-kD DNA结合蛋白的核衣壳、核关联及基因组定位

Nucleocapsid, nuclear association, and genome location of the herpes simplex virus type 2 38-kD DNA-binding protein.

作者信息

Burdett L A, Docherty J J, Howett M K

机构信息

Virology Laboratory, Pennsylvania State University, University Park.

出版信息

Intervirology. 1990;31(2-4):76-84. doi: 10.1159/000150141.

DOI:10.1159/000150141

PMID:2165049

Abstract

A previously-described herpes simplex virus type 2 DNA-binding protein with a molecular size of 38 kD has been further characterized. Using purified nucleocapsids, a DNase release assay, and intertypic recombinants, this protein was found to be a component of the nucleocapsid, intimately associated with the nuclear matrix, and encoded between 0.605 and 0.720 on the herpes simplex virus type 2 genome.

摘要

一种先前描述的分子大小为38kD的2型单纯疱疹病毒DNA结合蛋白已得到进一步鉴定。利用纯化的核衣壳、DNase释放试验和型间重组体，发现该蛋白是核衣壳的一个组成部分，与核基质密切相关，且由2型单纯疱疹病毒基因组上0.605至0.720之间的区域编码。