人类CD4辅助性T细胞激活：两种不同胶原受体1F7和VLA整合素家族的功能参与
Human CD4 helper T cell activation: functional involvement of two distinct collagen receptors, 1F7 and VLA integrin family.
作者信息
Dang N H, Torimoto Y, Schlossman S F, Morimoto C
机构信息
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
出版信息
J Exp Med. 1990 Aug 1;172(2):649-52. doi: 10.1084/jem.172.2.649.
Abstract
In the present study, we showed that activation of human CD4 T cells can be induced by anti-CD3 and collagen in a serum-free system. This activation was inhibited by the addition of peptides containing the RGD or Gly-Pro-X sequences. Significantly, we demonstrated that both the 1F7 (CD26) structure and the VLA integrin family, particularly the VLA-3 complex, contribute to the functional interaction between collagen and CD4 cells since anti-1F7 and anti-VLA-3 specifically inhibited this collagen-induced CD4 cell activation. Biochemical studies showed that the 1F7 structure is not a member of the VLA integrin family. These results thus indicated that two different families of antigens serve as functional collagen receptors for CD4 T cell activation.
摘要
在本研究中，我们发现，在无血清体系中，抗CD3和胶原蛋白可诱导人CD4 T细胞活化。添加含有RGD或Gly-Pro-X序列的肽可抑制这种活化。重要的是，我们证明1F7（CD26）结构和VLA整合素家族，特别是VLA-3复合物，参与了胶原蛋白与CD4细胞之间的功能相互作用，因为抗1F7和抗VLA-3特异性抑制了这种胶原蛋白诱导的CD4细胞活化。生化研究表明，1F7结构不是VLA整合素家族的成员。因此，这些结果表明，两类不同的抗原家族作为CD4 T细胞活化的功能性胶原蛋白受体。
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