Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA.
Vet J. 2012 Jan;191(1):41-5. doi: 10.1016/j.tvjl.2011.05.008. Epub 2011 Jun 8.
A total of 22,462 serum sample results from dogs being evaluated for gastrointestinal disease at the Gastrointestinal Laboratory, College of Veterinary Medicine, Texas A&M University were evaluated retrospectively. The proportion of dogs with serum cobalamin concentrations below the reference interval and median serum concentrations were compared between Shar Peis and other dog breeds. Serum samples were also obtained prospectively from 22 healthy and 32 Shar Peis with chronic gastrointestinal disease and 59 healthy dogs of other breeds, and serum concentrations of cobalamin, folate, and methylmalonic acid were determined and compared. Overall, 64.0% (89/139) of serum samples from Shar Peis showed serum cobalamin concentrations below the limit of the reference interval and 38.1% (53/139) of these were below the detectable limit for the assay. The median serum cobalamin concentration in Shar Peis was significantly lower than in other breeds. Shar Peis with gastrointestinal disease had significantly lower serum cobalamin and higher serum methylmalonic acid concentrations compared to healthy Shar Peis. Healthy Shar Peis had significantly increased serum methylmalonic acid concentrations compared to healthy dogs of other breeds. There were no meaningful differences in folate concentrations between groups. In conclusion, Shar Peis have a high prevalence of cobalamin deficiency compared to other breeds and healthy Shar Peis may have subclinical cobalamin deficiency.
对在德克萨斯 A&M 大学兽医学院胃肠道实验室接受胃肠道疾病评估的 22462 份犬血清样本的结果进行了回顾性评估。比较了沙皮犬和其他犬种的血清钴胺素浓度低于参考区间和中位数的比例。还前瞻性地从 22 只健康的和 32 只患有慢性胃肠道疾病的沙皮犬以及 59 只其他品种的健康犬中采集了血清样本，并测定和比较了钴胺素、叶酸和甲基丙二酸的血清浓度。总体而言，64.0%（89/139）的沙皮犬血清样本的钴胺素浓度低于参考区间的下限，其中 38.1%（53/139）低于检测限。沙皮犬的血清钴胺素浓度中位数明显低于其他品种。与健康的沙皮犬相比，患有胃肠道疾病的沙皮犬的血清钴胺素水平显著降低，血清甲基丙二酸水平显著升高。与其他品种的健康犬相比，健康的沙皮犬的血清甲基丙二酸浓度显著升高。各组间叶酸浓度无显著差异。总之，与其他品种相比，沙皮犬的钴胺素缺乏症患病率较高，而健康的沙皮犬可能存在亚临床的钴胺素缺乏症。
