Grützner Niels, Cranford Shannon M, Norby Bo, Suchodolski Jan S, Steiner Jörg M
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA.
J Vet Diagn Invest. 2012 Nov;24(6):1105-14. doi: 10.1177/1040638712461250. Epub 2012 Sep 26.
Altered serum cobalamin concentrations have been observed in dogs with gastrointestinal disorders such as exocrine pancreatic insufficiency (EPI) or gastrointestinal inflammation. The aims of the current study were 1) to identify breeds with a higher proportion of dogs with a decreased serum cobalamin concentration, 2) to determine whether dogs with such decreased concentrations tend to have serum canine trypsin-like immunoreactivity (cTLI) concentrations diagnostic for EPI, and 3) to compare the number of submissions for serum cobalamin analysis by breed to the American Kennel Club (AKC) breed ranking list of 2009. In this retrospective study, results of 28,675 cobalamin tests were reviewed. Akitas, Chinese Shar-Peis, German Shepherd Dogs, Greyhounds, and Labrador Retrievers had increased proportions of serum cobalamin concentrations below the lower limit of the reference interval (<251 ng/l; all P < 0.0001). Akitas, Chinese Shar-Peis, German Shepherd Dogs, and Border Collies had increased proportions of serum cobalamin concentrations below the detection limit of the assay (<150 ng/l; all P < 0.0001). Akitas, Border Collies, and German Shepherd Dogs with serum cobalamin concentrations <150 ng/l were more likely to have a serum cTLI concentration considered diagnostic for EPI (≤2.5 µg/l; all P ≤ 0.001). The breed with the highest proportion of samples submitted for serum cobalamin analysis in comparison with the AKC ranking list was the Greyhound (odds ratio: 84.6; P < 0.0001). In Akitas and Border Collies, further investigations are warranted to clarify if a potentially breed-specific gastrointestinal disorder is responsible for the increased frequency of decreased serum cobalamin and cTLI concentrations.
在患有胃肠疾病（如外分泌性胰腺功能不全（EPI）或胃肠道炎症）的犬中，已观察到血清钴胺素浓度发生改变。本研究的目的是：1）确定血清钴胺素浓度降低的犬比例较高的品种；2）确定血清钴胺素浓度降低的犬是否倾向于具有诊断EPI的血清犬胰蛋白酶样免疫反应性（cTLI）浓度；3）将各品种提交血清钴胺素分析的数量与美国养犬俱乐部（AKC）2009年的品种排名列表进行比较。在这项回顾性研究中，对28,675次钴胺素检测结果进行了审查。秋田犬、中国沙皮犬、德国牧羊犬、灵缇犬和拉布拉多寻回犬血清钴胺素浓度低于参考区间下限（<251 ng/l；所有P<0.0001）的比例增加。秋田犬、中国沙皮犬、德国牧羊犬和边境牧羊犬血清钴胺素浓度低于检测限（<150 ng/l；所有P<0.0001）的比例增加。血清钴胺素浓度<150 ng/l的秋田犬、边境牧羊犬和德国牧羊犬更有可能具有被认为可诊断EPI的血清cTLI浓度（≤2.5 µg/l；所有P≤0.001）。与AKC排名列表相比，提交血清钴胺素分析样本比例最高的品种是灵缇犬（优势比：84.6；P<0.0001）。对于秋田犬和边境牧羊犬，有必要进一步调查，以明确是否存在潜在的品种特异性胃肠疾病导致血清钴胺素和cTLI浓度降低的频率增加。
