允许性细胞、半允许性细胞和非允许性细胞对猴病毒40摄取的增强作用。

Enhancement of simian virus 40 uptake by permissive, semi-permissive and non-permissive cells.

作者信息

Tan K B

出版信息

Cytobios. 1977;20(79-80):143-9.

Abstract

The uptake of simian virus 40 (SV40) by cells that are both non-permissive for virus replication and resistant to virus infection could be enhanced markedly by infecting the cells in presence of DEAE-dextran. Virus uptake by semi-permissive and permissive cells was also enhanced by DEAE-dextran. Optimum enhancement of virus uptake occurred at 100 microgram of DEAE-dextran per ml and under the conditions employed, the polycation was not toxic to cells. The increased cellular uptake of virus may result from the uptake of virus aggregates formed in the presence of DEAE-dextran.

摘要

在存在二乙氨基乙基葡聚糖（DEAE - 葡聚糖）的情况下感染细胞，可显著增强对病毒复制不许可且对病毒感染有抗性的细胞对猿猴病毒40（SV40）的摄取。DEAE - 葡聚糖也增强了半许可细胞和许可细胞对病毒的摄取。在每毫升100微克DEAE - 葡聚糖时，病毒摄取的增强效果最佳，在所采用的条件下，这种聚阳离子对细胞无毒。细胞对病毒摄取的增加可能是由于摄取了在DEAE - 葡聚糖存在下形成的病毒聚集体。