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[电针对电休克的影响——阿片受体的放射自显影研究]

[Effect of electroacupuncture on electroconvulsive shock--an autoradiographic study for opioid receptors].

作者信息

He X P, Zhu J M, Huang D K, Li K Y, Cao X D

机构信息

Department of Neurobiology, Faculty of Basic Medical Sciences, Shanghai Medical University.

出版信息

Sheng Li Xue Bao. 1990 Apr;42(2):149-54.

PMID:2165280
Abstract

Radioreceptor-binding assay combined with autoradiography technique in the brain slices of rats was used to investigate cerebral areas related to electroconvulsive shock (ECS) and to analyze changes of opioid receptors of these areas in electroacupuncture (EA) anticonvulsion. The results from image processing and detection of optic density (O.D.) showed that repeated ECS resulted in an increase of opioid receptor densities in the caudate nucleus, hippocampus, habenulae nucleus and amygdala. In the group of EA plus ECS, however, the opioid receptor densities in the hippocampus, habenula nucleus and amygdala decreased as compared with that in ECS group. In addition, the receptor density in the caudate nucleus showed a decrease tendency. The results provided morphological evidence of the involvement of opioid receptors in these cerebral areas in the process of ECS and EA anticonvulsion.

摘要

采用放射受体结合分析法并结合大鼠脑片放射自显影技术,研究与电惊厥休克(ECS)相关的脑区,并分析这些脑区在电针(EA)抗惊厥过程中阿片受体的变化。图像处理和光密度(O.D.)检测结果显示,反复电惊厥休克导致尾状核、海马、缰核和杏仁核中阿片受体密度增加。然而,在电针加电惊厥休克组中,海马、缰核和杏仁核中的阿片受体密度与电惊厥休克组相比降低。此外,尾状核中的受体密度呈下降趋势。这些结果为阿片受体参与电惊厥休克和电针抗惊厥过程中的这些脑区提供了形态学证据。

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