Ijaola O, Falase A O
Department of Medicine, University College Hospital, Ibadan, Nigeria.
Afr J Med Med Sci. 1990 Jun;19(2):93-103.
The sera of eight endomyocardial fibrosis (EMF) subjects, 11 siblings of one of them and 16 normal children matched with the EMF patients for age, sex and socio-economic status from Ogunmakin and Shao/Oloru communities (eight each), situated in EMF-endemic and non-endemic areas of Nigeria respectively, were examined for the presence of antibodies against Coxsackie viruses B1-6, 16 arboviruses and Toxoplasma gondii. Sera from 36 other randomly selected normal children from Ogunmakin and 26 other randomly selected children from Shao/Oloru were also tested for the presence of antibodies against Toxoplasma gondii and the 16 arboviruses. None of the eight EMF subjects nor the 11 siblings of one of them had antibodies against any of the Coxsackie viruses B1-6 in their sera. Two of the 16 matched control subjects, one from each community, had positive antibodies, at equivocal titres against Coxsackie B1 (Ogunmakin) and B4 (Shao/Oloru). There was no significant difference in the distribution of antibody titres to the arboviruses between the EMF patients and matched controls. Normal children from the Shao/Oloru community had higher percentage antibody reactions and higher titres to the arboviruses compared with the children from Ogunmakin. All the eight EMF patients had high antibody titres against Toxoplasma gondii. Seven (87.5%) of the matched controls from Ogunmakin were sero-positive for Toxoplasma gondii compared with three (37.5%) of the matched controls from Shao/Oloru. Of the 36 normal children from Ogunmakin, 32 (88.9%) were sero-positive compared with 11 (42.3%) of the 26 normal children from Shao/Oloru. Four (36.4%) of the 11 siblings of one of the EMF patients had weak sero-positivity. It is therefore concluded that further studies are needed to clarify the role, if any, of Toxoplasma gondii in EMF.
对来自尼日利亚分别处于心肌内膜纤维化（EMF）流行区和非流行区的奥贡马金和绍/奥洛鲁社区（各8名）的8名EMF患者的血清、其中1名患者的11名亲属以及16名在年龄、性别和社会经济地位上与EMF患者匹配的正常儿童进行检测，以确定是否存在针对柯萨奇病毒B1 - 6、16种虫媒病毒和弓形虫的抗体。还对另外从奥贡马金随机选取的36名正常儿童以及从绍/奥洛鲁随机选取的26名儿童的血清进行检测，以确定是否存在针对弓形虫和16种虫媒病毒的抗体。8名EMF患者及其11名亲属的血清中均未检测到针对任何柯萨奇病毒B1 - 6的抗体。16名匹配对照受试者中有2名（每个社区各1名）抗体呈阳性，分别为针对柯萨奇B1（奥贡马金）和B4（绍/奥洛鲁）的可疑滴度。EMF患者和匹配对照之间针对虫媒病毒的抗体滴度分布没有显著差异。与奥贡马金的儿童相比，绍/奥洛鲁社区的正常儿童对虫媒病毒的抗体反应百分比更高，滴度也更高。所有8名EMF患者针对弓形虫的抗体滴度都很高。奥贡马金的匹配对照中有7名（87.5%）弓形虫血清学检测呈阳性，而绍/奥洛鲁的匹配对照中有3名（37.5%）呈阳性。奥贡马金的36名正常儿童中有32名（88.9%）血清学检测呈阳性，而绍/奥洛鲁的26名正常儿童中有11名（42.3%）呈阳性。1名EMF患者的11名亲属中有4名（36.4%）血清弱阳性。因此得出结论，需要进一步研究以阐明弓形虫在EMF中是否起作用及其作用如何。
