Enteric Diseases Reference Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Private Bag X4, Sandringham, 2131 Johannesburg, South Africa.
J Clin Microbiol. 2011 Aug;49(8):2976-9. doi: 10.1128/JCM.00293-11. Epub 2011 Jun 8.
Thirty-one antimicrobial-resistant, extended-spectrum-β-lactamase-producing strains of Vibrio cholerae O1 serotype Ogawa associated with an outbreak of cholera in South Africa (2008) were investigated. Ten selected cholera strains were PCR positive for the SXT element, harbored mutations in the quinolone resistance-determining regions of GyrA (Ser83-Ile) and ParC (Ser85-Leu), and produced TEM-63 β-lactamase.
对 2008 年南非霍乱暴发中与弧菌属霍乱 O1 血清型 Ogawa 相关的 31 株具有抗药性、产超广谱β-内酰胺酶的菌株进行了调查。10 株选定的霍乱菌株 SXT 元件 PCR 阳性,gyrA(丝氨酸 83 到异亮氨酸)和 parC(丝氨酸 85 到亮氨酸)喹诺酮耐药决定区突变,并产生 TEM-63β-内酰胺酶。