Csábi Eszter, Janacsek Karolina, Várszegi Mária, Németh Dezsô
SZTE BTK Nevelestudomanyi Doktori Iskola, Szeged, Hungary.
Psychiatr Hung. 2011;26(2):78-86.
In obstructive sleep apnea syndrome (OSAS) hypoxia and sleep deprivation lead to neuropsychological impairments. Our goal in this study to evaluate working memory and skill learning to get a complex picture about cortical and sub-cortical function in patients with sleep apnea. Twenty-one OSAS patients and 21 healthy controls participated in the study. We analyzed verbal-, vizuo-spatial, complex working memory, general skill learning and sequence specific learning separately. Our data show that complex working memory was impaired in OSAS patients, in contrary OSAS patients represented better achievement in the vizuo-spatial task compared to the control group. We found that OSAS patients showed general skill learning and implicit learning of probabilistic sequences similar to that of controls. Taken together, we found dissociation between working memory and implicit sequence learning in OSAS. These findings suggest that sleep has less influence on the functions related to sub-cortical structures like cortical functions.
在阻塞性睡眠呼吸暂停综合征（OSAS）中，缺氧和睡眠剥夺会导致神经心理损伤。我们在本研究中的目标是评估工作记忆和技能学习，以全面了解睡眠呼吸暂停患者的皮质和皮质下功能。21名OSAS患者和21名健康对照者参与了该研究。我们分别分析了言语、视觉空间、复杂工作记忆、一般技能学习和序列特异性学习。我们的数据表明，OSAS患者的复杂工作记忆受损，相反，与对照组相比，OSAS患者在视觉空间任务中的表现更好。我们发现，OSAS患者的一般技能学习和概率序列的隐性学习与对照组相似。综合来看，我们发现OSAS患者的工作记忆和隐性序列学习之间存在分离。这些发现表明，睡眠对与皮质下结构相关的功能（如皮质功能）的影响较小。
