Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Nat Rev Cancer. 2011 Jun 9;11(7):481-92. doi: 10.1038/nrc3068.
SWI/SNF chromatin remodelling complexes use the energy of ATP hydrolysis to remodel nucleosomes and to modulate transcription. Growing evidence indicates that these complexes have a widespread role in tumour suppression, as inactivating mutations in several SWI/SNF subunits have recently been identified at a high frequency in a variety of cancers. However, the mechanisms by which mutations in these complexes drive tumorigenesis are unclear. In this Review we discuss the contributions of SWI/SNF mutations to cancer formation, examine their normal functions and discuss opportunities for novel therapeutic interventions for SWI/SNF-mutant cancers.
SWI/SNF 染色质重塑复合物利用 ATP 水解的能量重塑核小体并调节转录。越来越多的证据表明，这些复合物在肿瘤抑制中具有广泛的作用，因为最近在各种癌症中高频发现了几种 SWI/SNF 亚基的失活突变。然而，这些复合物中的突变驱动肿瘤发生的机制尚不清楚。在这篇综述中，我们讨论了 SWI/SNF 突变对癌症形成的贡献，研究了它们的正常功能，并讨论了针对 SWI/SNF 突变型癌症的新型治疗干预的机会。
