年龄相关性黄斑变性
Age-related macular degeneration.
作者信息
Querques Giuseppe, Avellis Fernando Onofrio, Querques Lea, Bandello Francesco, Souied Eric H
机构信息
Service d'Ophtalmologie, Centre Hospitalier Intercommunal Créteil, Université Paris-Est Créteil, Créteil, France;
出版信息
Clin Ophthalmol. 2011;5:593-601. doi: 10.2147/OPTH.S10161. Epub 2011 May 18.
CLINICAL QUESTION
Is there any new knowledge about the pathogenesis and treatment of age-related macular degeneration (AMD)?
RESULTS
We now understand better the biochemical and pathological pathways involved in the genesis of AMD. Treatment of exudative AMD is based on intravitreal injection of new antivascular endothelial growth factor drugs for which there does not yet exist a unique recognized strategy of administration. No therapies are actually available for atrophic AMD, despite some experimental new pharmacological approaches.
IMPLEMENTATION
strategy of administration, safety of intravitreal injection.
临床问题
关于年龄相关性黄斑变性（AMD）的发病机制和治疗有哪些新知识？
结果
我们现在对AMD发生过程中涉及的生化和病理途径有了更好的理解。渗出性AMD的治疗基于玻璃体内注射新型抗血管内皮生长因子药物，目前尚无统一认可的给药策略。尽管有一些新的实验性药理学方法，但目前尚无针对萎缩性AMD的有效疗法。
实施
给药策略、玻璃体内注射的安全性。
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