Park Joo Youn, Kim Seung Hoon, Park Tae Kwann, Ohn Young-Hoon
Department of Ophthalmology, Soonchunhyang University College of Medicine, Bucheon, Korea.
Korean J Ophthalmol. 2011 Jun;25(3):161-5. doi: 10.3341/kjo.2011.25.3.161. Epub 2011 May 24.
To evaluate the changes in multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) after intravitreal bevacizumab injection in the treatment of age-related macular degeneration (AMD).
Twenty-one eyes with choroidal neovascularization secondary to AMD were studied before and after intravitreal bevacizumab injection for best corrected visual acuity (BCVA), OCT, and mfERG.
The BCVA improved, while central macular thickness and total macular volume in OCT decreased after intravitreal bevacizumab injection (p = 0.03, 0.01, and 0.01, respectively). In mfERG, the amplitude of P1, and implicit time of P1 and N1 indicated a statistically significant improvement of retinal response after intravitreal bevacizumab injection.
There is a potential role for mfERG in evaluating the effect on retinal function of intravitreal bevacizumab injection.
评估玻璃体内注射贝伐单抗治疗年龄相关性黄斑变性（AMD）后多焦视网膜电图（mfERG）和光学相干断层扫描（OCT）的变化。
对21只继发于AMD的脉络膜新生血管眼在玻璃体内注射贝伐单抗前后进行最佳矫正视力（BCVA）、OCT和mfERG检查。
玻璃体内注射贝伐单抗后，BCVA提高，OCT显示黄斑中心厚度和黄斑总体积减小（p分别为0.03、0.01和0.01）。在mfERG中，P1波幅以及P1和N1波的隐含时间表明玻璃体内注射贝伐单抗后视网膜反应有统计学意义的改善。
mfERG在评估玻璃体内注射贝伐单抗对视网膜功能的影响方面具有潜在作用。
