Department of Medicine, Justus-Liebig-University, Friedrichstraße 24, 35392 Giessen, Germany.
Hamostaseologie. 2011 Aug;31(3):174-6, 177-8. doi: 10.5482/ha-1159. Epub 2011 Jun 8.
Factor VII activating protease (FSAP) is a circulating serine protease with high homology to fibrinolytic enzymes. A role in the regulation of coagulation and fibrinolysis is suspected based on in vitro studies demonstrating activation of FVII or pro-urokinase plasminogen activator (uPA). However, considering the paucity of any studies in animal models or any correlative studies in humans the role of FSAP in haemostasis remains unclear. In relation to vascular remodeling processes or inflammation it has been convincingly shown that FSAP interacts with growth factors as well as protease activated receptors (PAR). Against this sparse background there are a plethora of studies which have investigated the linkage of single nucleotide polymorphisms (SNP) in the FSAP gene (HABP2) to various diseases. The G534E SNP of FSAP is associated with a low proteolytic activity due to an amino acid exchange in the protease domain. This and other SNPs have been linked to carotid stenosis, stroke as well as thrombosis in the elderly and plaque calcification. These SNP analyses indicate an important role for FSAP in the regulation of the haemostasis system as well as fibroproliferative inflammatory processes.
因子 VII 激活蛋白酶（FSAP）是一种循环丝氨酸蛋白酶，与纤维蛋白溶解酶具有高度同源性。基于体外研究表明其可激活 FVII 或组织型纤溶酶原激活物（uPA），提示其在凝血和纤溶调节中具有作用。但是，考虑到在动物模型中几乎没有任何研究或在人类中进行的任何相关性研究，FSAP 在止血中的作用仍然不清楚。在涉及血管重塑过程或炎症的情况下，已经令人信服地表明 FSAP 与生长因子以及蛋白酶激活受体（PAR）相互作用。在这种稀少的背景下，有大量研究调查了 FSAP 基因（HABP2）中单核苷酸多态性（SNP）与各种疾病之间的联系。由于蛋白酶结构域中的氨基酸置换，FSAP 的 G534E SNP 与其低蛋白水解活性相关。该 SNP 及其他 SNP 与颈动脉狭窄、中风以及老年血栓形成和斑块钙化有关。这些 SNP 分析表明 FSAP 在止血系统以及纤维增生性炎症过程的调节中具有重要作用。
