Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.
Hamostaseologie. 2012;32(1):51-5. doi: 10.5482/ha-1187.
Factor VII-activating protease (FSAP) is a serine protease in plasma that has a role in coagulation and fibrinolysis. FVII could be activated by purified FSAP in a tissue factor independent manner and pro-urokinase has been demonstrated to be a substrate for purified FSAP in-vitro. However, the physiological role of FSAP in haemostasis remains unclear. More recently FSAP is suggested to be involved in inflammation. It modulates vascular permeability directly and indirectly by the generation of bradykinin. Furthermore, FSAP is activated by dead cells induced by the inflammatory response and subsequently removes nucleosomes from apoptotic cells. FSAP activation can be detected in sepsis patients as well. However, whether FSAP activation upon inflammation is beneficial or detrimental remains an open question. In this review the structure, activation mechanisms and the possible role of FSAP in inflammation are discussed.
因子 VII 激活蛋白酶（FSAP）是血浆中的一种丝氨酸蛋白酶，在凝血和纤维蛋白溶解中发挥作用。FVII 可以通过纯化的 FSAP 以组织因子非依赖性方式激活，并且已经证明原尿激酶是纯化的 FSAP 在体外的底物。然而，FSAP 在止血中的生理作用尚不清楚。最近 FSAP 被认为参与炎症。它通过生成缓激肽直接和间接调节血管通透性。此外，FSAP 通过炎症反应诱导的死亡细胞激活，随后从凋亡细胞中去除核小体。在败血症患者中也可以检测到 FSAP 的激活。然而，炎症时 FSAP 的激活是有益还是有害仍然是一个悬而未决的问题。在这篇综述中，讨论了 FSAP 的结构、激活机制以及在炎症中的可能作用。
