[催产素对可食用蜗牛神经元中电压激活钙电流的影响]
[The effect of oxytocin on the potential-activated calcium current in the neurons of the edible snail].
作者信息
Kononeko N I, Shcherbatko A D
出版信息
Neirofiziologiia. 1990;22(2):272-5.
PMID:2165575
Abstract
Effect of oxytocin and other peptides on the potential-activated calcium current was studied in neurons of the snail Helix pomatia under clamp conditions. It has been found that oxytocin inhibits the calcium current and ED50 of this process is about 9 x 10(-7) mol/l. Vasopressin has the same effect on the calcium current with ED50 about 8 x 10(-6) mol/l. Des-Gly-vasopressin exerts no noticeable effect on the calcium current. Possible mechanisms of the inhibitory effect of oxytocin on the calcium current are discussed.
摘要
在钳制条件下，研究了催产素和其他肽对苹果螺神经元中电压激活钙电流的影响。已发现催产素可抑制钙电流，此过程的半数有效剂量（ED50）约为9×10⁻⁷mol/L。血管加压素对钙电流有相同作用，其ED50约为8×10⁻⁶mol/L。去甘氨酸血管加压素对钙电流无明显影响。文中讨论了催产素对钙电流产生抑制作用的可能机制。
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