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[微量离子电渗法注射AMP和cAMP对可食蜗牛透析神经元钙电流的影响]

[Effect of the microiontophoretic injection of AMP and cAMP on the calcium current in the dialyzed neuron of the edible snail].

作者信息

Kononenko N I, Shcherbatko A D

出版信息

Neirofiziologiia. 1988;20(6):769-76.

PMID:2854882
Abstract

The effect of microiontophoretic injection of AMP and cAMP on the calcium current was investigated in dialyzed snail neurons. It was found that microiontophoretic injection of AMP restores calcium current after its "washout" during the dialysis and enhances its stability. In this case the current-voltage characteristic was shifted by 10 mV in the depolarizing direction. Under these conditions the iontophoretic cAMP injection into a dialyzed neuron produced a reversible decrease of the calcium current.

摘要

在经透析的蜗牛神经元中研究了微量离子电渗法注射AMP和cAMP对钙电流的影响。结果发现,微量离子电渗法注射AMP可在透析过程中钙电流“洗脱”后恢复该电流,并增强其稳定性。在这种情况下,电流-电压特性在去极化方向上偏移了10 mV。在这些条件下,向经透析的神经元中离子电渗法注射cAMP会使钙电流产生可逆性降低。

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