Solov'eva N I, Volkova Z I, Mul'diiarov P Ia
Revmatologiia (Mosk). 1990 Jan-Mar(1):46-50.
The authors made a comparative study of collagenolytic (CA) and neutral caseinolytic activity (NCA) in the cells of the synovial fluid (CSF) depending on the peculiarities of the course of rheumatoid process and also on the duration of the disease prior to and after treatment of rheumatoid arthritis (RA). It has been shown that proteinase is one of the factors of RA pathogenesis. The level of enzymes directly depended on the activity of synovitis. The data obtained show that with a rapidly progressing RA and also with the III degree of the disease activity, CA in CSF were twice as high as those observed with a slowly progressing RA and also with the I-II degree of RA activity. The treatment conducted promoted a rise in CA, NCA in CSF. The possible mechanism of these processes is being discussed.
作者根据类风湿病程的特点以及类风湿关节炎（RA）治疗前后疾病的持续时间，对滑液液液液（CSF）细胞中的胶原分解活性（CA）和中性酪蛋白分解活性（NCA）进行了比较研究。结果表明，蛋白酶是RA发病机制的因素之一。酶的水平直接取决于滑膜炎的活性。所得数据表明，在快速进展的RA以及疾病活动III度时，CSF中的CA是缓慢进展的RA以及RA活动I-II度时的两倍。所进行的治疗促进了CSF中CA、NCA的升高。正在讨论这些过程的可能机制。
