Parkinson's Disease Research, Education and Clinical Center, Philadelphia VA Medical Center and Department of Neurology, University of Pennsylvania School of Medicine. Philadelphia, PA 19104, USA.
J Neurol Sci. 2011 Nov 15;310(1-2):228-30. doi: 10.1016/j.jns.2011.05.030. Epub 2011 Jun 11.
Olfactory impairment is a common early non-motor manifestation in Parkinson's disease that has garnered interest as a clinical biomarker for early "pre-motor" diagnosis and prediction of associated clinical phenotypes. Whether olfactory impairment correlates well with motor symptoms is not yet clear, and recent interest has focused on the relationship between hyposmia and other non-motor symptoms. In this paper, we will review emerging evidence for a relationship between hyposmia and neuropsychiatric manifestations, discussing the potential pathophysiology together with challenges and opportunities for future research.
嗅觉障碍是帕金森病常见的早期非运动表现，它作为一种早期“运动前期”诊断的临床生物标志物以及相关临床表型的预测指标引起了人们的兴趣。嗅觉障碍与运动症状是否密切相关尚不清楚，最近的研究重点关注了嗅觉障碍与其他非运动症状之间的关系。在本文中，我们将综述嗅觉障碍与神经精神表现之间关系的新证据，讨论潜在的病理生理学以及未来研究的挑战和机遇。
