LabelHash 服务器和基于结构的功能注释工具。

The LabelHash server and tools for substructure-based functional annotation.

机构信息

Department of Computer Science, Rice University, Houston, TX 77005, USA.

出版信息

Bioinformatics. 2011 Aug 1;27(15):2161-2. doi: 10.1093/bioinformatics/btr343. Epub 2011 Jun 8.

DOI:10.1093/bioinformatics/btr343

PMID:21659320

Abstract

SUMMARY

The LabelHash server and tools are designed for large-scale substructure comparison. The main use is to predict the function of unknown proteins. Given a set of (putative) functional residues, LabelHash finds all occurrences of matching substructures in the entire Protein Data Bank, along with a statistical significance estimate and known functional annotations for each match. The results can be downloaded for further analysis in any molecular viewer. For Chimera, there is a plugin to facilitate this process.

AVAILABILITY

The web site is free and open to all users with no login requirements at http://labelhash.kavrakilab.org

摘要

LabelHash 服务器和工具专为大规模子结构比较而设计。其主要用途是预测未知蛋白质的功能。给定一组（假定的）功能残基，LabelHash 在整个蛋白质数据库中找到所有匹配子结构的出现，并为每个匹配提供统计显著性估计和已知的功能注释。结果可以下载到任何分子查看器中进行进一步分析。对于 Chimera，有一个插件可以方便这个过程。