Department of Internal Medicine, Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA.
Obesity (Silver Spring). 2011 Sep;19(9):1761-7. doi: 10.1038/oby.2011.146. Epub 2011 Jun 9.
Obesity is one of the most prevalent health problems in the United States. Current therapeutic strategies for the treatment of obesity are unsatisfactory. We hypothesized the use of colon electrical stimulation (CES) to treat obesity by inhibiting upper gastrointestinal motility. In this preliminary study, we aimed at studying the effects of CES on gastric emptying of solid, intestinal motility, and food intake in dogs. Six dogs, equipped with serosal colon electrodes and a jejunal cannula, were randomly assigned to receive sham-CES or CES during the assessment of: (i) gastric emptying of solids, (ii) postprandial intestinal motility, (iii) autonomic functions, and (iv) food intake. We found that (i) CES delayed gastric emptying of solids by 77%. Guanethidine partially blocked the inhibitory effect of CES on solid gastric emptying; (ii) CES significantly reduced intestinal contractility and the effect lasted throughout the recovery period; (iii) CES decreased vagal activity in both fasting and fed states, increased the sympathovagal balance and marginally increased sympathetic activity in the fasting state; (iv) CES resulted in a reduction of 61% in food intake. CES reduces food intake in healthy dogs and the anorexigenic effect may be attributed to its inhibitory effects on gastric emptying and intestinal motility, mediated via the autonomic mechanisms. Further studies are warranted to investigate the therapeutic potential of CES for obesity.
肥胖是美国最普遍的健康问题之一。目前治疗肥胖的策略并不令人满意。我们假设通过抑制上胃肠道动力来使用结肠电刺激（CES）来治疗肥胖。在这项初步研究中，我们旨在研究 CES 对固体胃排空、肠道动力和犬食物摄入的影响。六只狗配备了浆膜结肠电极和空肠套管，随机分为假 CES 或 CES 治疗组，以评估：（i）固体胃排空，（ii）餐后肠道动力，（iii）自主功能和（iv）食物摄入。我们发现，（i）CES 使固体胃排空延迟了 77%。胍乙啶部分阻断了 CES 对固体胃排空的抑制作用；（ii）CES 显著降低了肠道收缩力，其作用持续整个恢复期；（iii）CES 降低了空腹和进食状态下的迷走神经活动，增加了空腹时的交感神经-迷走神经平衡，并适度增加了交感神经活动；（iv）CES 导致食物摄入量减少了 61%。CES 减少了健康犬的食物摄入，其厌食作用可能归因于其对胃排空和肠道动力的抑制作用，这是通过自主机制介导的。需要进一步的研究来探讨 CES 治疗肥胖的治疗潜力。
