Mintchev Martin P
Department of Electrical and Computer Engineering, University of Calgary, Calgary, AB, Canada T2N 1N4 ; Department of Surgery, University of Alberta, Edmonton, AB, Canada T6G 2B7.
ISRN Gastroenterol. 2013;2013:434706. doi: 10.1155/2013/434706. Epub 2013 Feb 7.
(a) conservative approaches and (b) invasive techniques. However, only invasive surgical methods have delivered significant and sustainable benefits. Therefore, contemporary research exploration has focused on the development of minimally invasive gastric manipulation methods featuring a safe but reliable and long-term sustainable weight loss effect similar to the one delivered by bariatric surgeries. This antiobesity approach is based on placing external devices in the stomach ranging from electrodes for gastric electrical stimulation to temporary intraluminal bezoars for gastric volume displacement for a predetermined amount of time. The present paper examines the evolution of these techniques from invasively implantable units to completely noninvasive patient-controllable implements, from a functional, rather than from the traditional, parametric point of view. Comparative discussion over the available pilot and clinical studies related to gastric electrical stimulation outlines the promises and the fallacies of this concept as a reliable alternative anti-obesity strategy.
全球肥胖症流行趋势日益加剧，促使了两种主要治疗方法的发展：（a）保守方法和（b）侵入性技术。然而，只有侵入性手术方法带来了显著且可持续的益处。因此，当代研究探索聚焦于开发微创胃部操作方法，这些方法具有安全可靠且长期可持续的减肥效果，类似于减肥手术所带来的效果。这种抗肥胖方法基于在胃内放置外部装置，从用于胃电刺激的电极到用于在预定时间内实现胃容量置换的临时腔内胃石。本文从功能而非传统参数的角度，审视了这些技术从侵入性可植入装置到完全无创且患者可控制器具的演变过程。对与胃电刺激相关的现有试点研究和临床研究的比较讨论，概述了这一概念作为一种可靠的替代抗肥胖策略的前景与误区。
