诱导型一氧化氮合酶基因多态性与石棉肺风险
Inducible nitric oxide synthase genetic polymorphism and risk of asbestosis.
作者信息
Franko Alenka, Dodič-Fikfak Metoda, Arnerić Niko, Dolžan Vita
机构信息
Clinical Institute of Occupational Medicine, University Medical Center, Poljanski Nasip 58, 1000 Ljubljana, Slovenia.
出版信息
J Biomed Biotechnol. 2011;2011:685870. doi: 10.1155/2011/685870. Epub 2011 May 24.
Asbestos, a known occupational pollutant, may upregulate the activity of inducible nitric oxide synthase (iNOS) and thus the production of nitric oxide (NO). This study investigated whether iNOS (CCTTT)(n) polymorphism is associated with an increased asbestosis risk in exposed workers. The study cohort consisted of 262 cases with asbestosis and 265 controls with no asbestos-related disease. For each subject the cumulative asbestos exposure data were available. The number of CCTTT repeats was determined following PCR amplification of the iNOS promoter region. Logistic regression was performed to estimate asbestosis risk. The OR of asbestosis was 1.20 (95% CI = 0.85-1.69) for the LL genotype compared to the combined SL and SS genotypes and 1.26 (95% CI = 0.86-1.85) for the LL genotype compared to the SL genotype. The results of this study are borderline significant and suggest a possible role of iNOS (CCTTT)(n) polymorphism in the risk of asbestosis; however, further studies are needed.
石棉是一种已知的职业污染物，可能会上调诱导型一氧化氮合酶（iNOS）的活性，从而增加一氧化氮（NO）的产生。本研究调查了iNOS（CCTTT）（n）多态性是否与接触石棉的工人患石棉沉着病风险增加有关。研究队列包括262例石棉沉着病患者和265例无石棉相关疾病的对照。每位受试者的累积石棉接触数据均可用。在对iNOS启动子区域进行PCR扩增后，确定CCTTT重复序列的数量。进行逻辑回归以评估石棉沉着病风险。与SL和SS基因型组合相比，LL基因型患石棉沉着病的OR为1.20（95%CI=0.85-1.69），与SL基因型相比，LL基因型患石棉沉着病的OR为1.26（95%CI=0.86-1.85）。本研究结果接近显著，提示iNOS（CCTTT）（n）多态性在石棉沉着病风险中可能起作用；然而，还需要进一步研究。
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