Koletsa Triantafyllia, Petrakis Georgios, Karayannopoulou Georgia, Pappas Dimitrios, Markou Konstantinos, Karkavelas Georgios, Kostopoulos Ioannis
Department of Pathology, Medical School, Aristotle University of Thessaloniki, 54009 Thessaloniki, Greece.
Patholog Res Int. 2011;2011:340763. doi: 10.4061/2011/340763. Epub 2011 May 31.
Synchronous malignancy of squamous cell carcinoma and malignant lymphoma in the head and neck region is extremely rare. Nasopharyngeal carcinoma is a nonlymphomatous, squamous cell carcinoma that occurs in the nasopharyngeal epithelium. Reported herein is a unique case of nasopharyngeal carcinoma occurring simultaneously with MALT-type lymphoma in an 83-year-old woman, who complained of deglutition dysfunction. Endoscopic examination of respective organs revealed a submucosal tumour on the posterior wall of pharynx. Biopsy of the hypopharynx was taken and sent for histological examination, which revealed two different neoplasms. Immunohistochemical and molecular analysis confirmed the diagnosis of nasopharyngeal carcinoma coexisting with a MALT-type lymphoma.
头颈部区域同时发生鳞状细胞癌和恶性淋巴瘤极为罕见。鼻咽癌是一种发生于鼻咽上皮的非淋巴瘤性鳞状细胞癌。本文报告了一例83岁女性同时发生鼻咽癌和黏膜相关淋巴组织（MALT）型淋巴瘤的独特病例，该患者主诉吞咽功能障碍。对各个器官进行内镜检查发现咽后壁有一个黏膜下肿瘤。对下咽进行活检并送去做组织学检查，结果显示为两种不同的肿瘤。免疫组织化学和分子分析证实了鼻咽癌与MALT型淋巴瘤共存的诊断。
