Sordi Emiliano, Cagossi Katia, Lazzaretti Maria Grazia, Gusolfino Daniel, Artioli Fabrizio, Santacroce Giovanni, Brandi Maria Luisa, Piscitelli Prisco
Ramazzini Hospital, Division of Oncology, 41012 Carpi, Italy.
Case Rep Med. 2011;2011:940803. doi: 10.1155/2011/940803. Epub 2011 Oct 11.
Breast cancer in men is uncommon, and even more rare is the simultaneous presentation of two different malignancies. A 39-year-old man was diagnosed with both breast cancer and axillary lymphoma. Familiar history revealed that his mother died because of breast cancer. The patient underwent fine needle aspiration leading to the diagnosis of malignant lesion. Modified radical mastectomy was performed. Histology revealed an infiltrating ductal carcinoma 2.8 cm wide, grade 2, with vascular and lymphatic invasion. Surprisingly, one of the second level nodes was confirmed as a high-grade large B cell non-Hodgkin's lymphoma. No family inheritance or gene mutations (BRCA 1 and 2) were found. The patient underwent local radiotherapy, followed by 6 chemotherapy courses (RCHOP) and treatment with tamoxifen 20 mg/daily. To our knowledge, this is the first case reported in literature of male breast cancer and axillary lymphoma simultaneously confirmed in the same patient.
男性乳腺癌并不常见，而同时出现两种不同的恶性肿瘤则更为罕见。一名39岁男性被诊断出患有乳腺癌和腋窝淋巴瘤。家族史显示他的母亲死于乳腺癌。患者接受了细针穿刺，从而诊断出恶性病变。进行了改良根治性乳房切除术。组织学检查显示为浸润性导管癌，直径2.8厘米，2级，伴有血管和淋巴管侵犯。令人惊讶的是，二级淋巴结之一被确认为高级别大B细胞非霍奇金淋巴瘤。未发现家族遗传或基因突变（BRCA 1和2）。患者接受了局部放疗，随后进行了6个疗程的化疗（RCHOP），并每日服用20毫克他莫昔芬进行治疗。据我们所知，这是文献中报道的首例在同一患者中同时确诊为男性乳腺癌和腋窝淋巴瘤的病例。
