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高产前和产后铅暴露相关的婴儿铅脑病。

High prenatal and postnatal lead exposure associated lead encephalopathy in an infant.

机构信息

Department of Pediatrics, Division of PICU and Emergency, Kalawati Saran Children's Hospital, New Delhi 11001, India.

出版信息

Indian J Pediatr. 2011 Nov;78(11):1420-3. doi: 10.1007/s12098-011-0445-6. Epub 2011 Jun 10.

DOI:10.1007/s12098-011-0445-6
PMID:21660408
Abstract

An 11-month-old child presented with persistent seizures requiring ventilator support. The child had global developmental delay, was staying in the premises of battery manufacturing unit, had microcytic and hypochromic anemia with basophilic stripling on peripheral smear, lead line on radiograph of the long bones and BLL of 244 μg/dl. The CT scan of the brain revealed cerebral atrophy. The mother also had high BLL and lead line in the radiograph of the long bones. The child was managed with chelation therapy. Given the continuing lead exposure among occupational and general populations in India, this case study highlights the need for prompt environmental preventive actions as well as nutritional and preventive counseling for occupational populations.

摘要

一名 11 个月大的儿童出现持续性癫痫发作,需要呼吸机支持。该儿童存在全面发育迟缓,居住在电池制造单位内,外周血涂片显示小细胞低色素性贫血伴嗜碱性点彩,长骨 X 线片有铅线,血铅水平为 244μg/dl。脑部 CT 扫描显示脑萎缩。母亲的长骨 X 线片也有高血铅和铅线。患儿接受了螯合疗法。鉴于印度职业人群和普通人群中持续存在铅暴露,本病例研究强调了需要及时采取环境预防措施,以及对职业人群进行营养和预防咨询。

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High prenatal and postnatal lead exposure associated lead encephalopathy in an infant.高产前和产后铅暴露相关的婴儿铅脑病。
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2
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引用本文的文献

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本文引用的文献

1
Determinants of lead level in umbilical cord blood.脐血中铅含量的决定因素。
Indian Pediatr. 2009 Sep;46(9):791-3. Epub 2009 Jan 21.
2
Lead exposure in children: prevention, detection, and management.儿童铅暴露:预防、检测与管理。
Pediatrics. 2005 Oct;116(4):1036-46. doi: 10.1542/peds.2005-1947.
3
Blood lead levels in children after phase-out of leaded gasoline in Bombay, India.印度孟买逐步淘汰含铅汽油后儿童的血铅水平。
Sci Total Environ. 2006 Jun 15;363(1-3):95-106. doi: 10.1016/j.scitotenv.2005.06.033. Epub 2005 Sep 19.
4
Low-level environmental lead exposure and children's intellectual function: an international pooled analysis.低水平环境铅暴露与儿童智力功能:一项国际汇总分析。
Environ Health Perspect. 2005 Jul;113(7):894-9. doi: 10.1289/ehp.7688.
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Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry.螯合疗法对入学后铅暴露儿童神经心理和行为发育的影响。
Pediatrics. 2004 Jul;114(1):19-26. doi: 10.1542/peds.114.1.19.
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Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter.血铅浓度低于每分升10微克的儿童的智力障碍。
N Engl J Med. 2003 Apr 17;348(16):1517-26. doi: 10.1056/NEJMoa022848.
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Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective study.母体骨铅作为胎儿神经毒性的独立危险因素:一项前瞻性研究。
Pediatrics. 2002 Jul;110(1 Pt 1):110-8. doi: 10.1542/peds.110.1.110.
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Mobilization of lead from the skeleton during the postnatal period is larger than during pregnancy.出生后骨骼中铅的动员量比怀孕期间更大。
J Lab Clin Med. 1998 Apr;131(4):324-9. doi: 10.1016/s0022-2143(98)90182-2.
9
A randomized trial of the effect of dust control on children's blood lead levels.一项关于粉尘控制对儿童血铅水平影响的随机试验。
Pediatrics. 1996 Jul;98(1):35-40.