MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
Behav Genet. 2011 Sep;41(5):668-79. doi: 10.1007/s10519-011-9473-2. Epub 2011 Jun 10.
Attention deficit hyperactivity disorder (ADHD) is characterised by developmentally inappropriate and impairing levels of inattentive and hyperactive-impulsive behaviours. We aimed to investigate the differential effects of parent and teacher ratings on inattention and hyperactivity-impulsivity and the extent of genetic overlap between the two behavioural dimensions. Multivariate structural equation modelling was performed on DSM-IV based ADHD ratings by parents and teachers collected on a general population sample of 672 twin pairs, at ages 7-10 years. This study is the first to simultaneously use parent and teacher ratings in twin modelling to examine the effects of different raters on the two behavioural dimensions of ADHD. The findings indicated that hyperactivity-impulsivity and inattention load on to separate latent factors that represent a common behavioural view for both parents and teachers, although there are additional aspects to the observations of these behaviours that are unique to each type of rater. The findings further indicate some shared aetiology for hyperactivity-impulsivity and inattention as measured by both parent and teacher ratings, in agreement with previous findings on the aetiology of the two symptom dimensions of ADHD.
注意缺陷多动障碍（ADHD）的特征是注意力不集中和多动冲动行为在发展上不适当和受损。我们旨在研究父母和教师评定对注意力不集中和多动冲动的不同影响，以及这两个行为维度之间遗传重叠的程度。使用基于 DSM-IV 的 ADHD 父母和教师评定，对 672 对双胞胎的一般人群样本在 7-10 岁时进行多变量结构方程建模。这项研究首次在双胞胎模型中同时使用父母和教师的评定来检查不同评定者对 ADHD 的两个行为维度的影响。研究结果表明，多动冲动和注意力不集中分别加载到代表父母和教师共同行为观点的独立潜在因素上，尽管对于这些行为的观察还有其他独特的方面。研究结果进一步表明，父母和教师评定的多动冲动和注意力不集中具有一些共同的病因，这与 ADHD 两个症状维度病因的先前发现一致。
