弓形虫中的组织蛋白酶蛋白酶。
Cathepsin proteases in Toxoplasma gondii.
机构信息
Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
出版信息
Adv Exp Med Biol. 2011;712:49-61. doi: 10.1007/978-1-4419-8414-2_4.
Abstract
Cysteine proteases are important for the growth and survival of apicomplexan parasites that infect humans. The apicomplexan Toxoplasma gondii expresses five members of the C1 family of cysteine proteases, including one cathepsin L-like (TgCPL), one cathepsin B-like (TgCPB) and three cathepsin C-like (TgCPC1, 2 and 3) proteases. Recent genetic, biochemical and structural studies reveal that cathepsins function in microneme and rhoptry protein maturation, host cell invasion, replication and nutrient acquisition. here, we review the key features and roles of T. gondii cathepsins and discuss the therapeutic potential for specific inhibitor development.
摘要
半胱氨酸蛋白酶对于感染人类的顶复门寄生虫的生长和存活很重要。顶复门的刚地弓形虫表达五个半胱氨酸蛋白酶 C1 家族成员，包括一个组织蛋白酶 L 样（TgCPL）、一个组织蛋白酶 B 样（TgCPB）和三个组织蛋白酶 C 样（TgCPC1、2 和 3）蛋白酶。最近的遗传、生化和结构研究表明，组织蛋白酶在微线体和棒状体蛋白成熟、宿主细胞入侵、复制和营养获取中发挥作用。在这里，我们回顾了刚地弓形虫组织蛋白酶的关键特征和作用，并讨论了特异性抑制剂开发的治疗潜力。
相似文献
1
Cathepsin proteases in Toxoplasma gondii.弓形虫中的组织蛋白酶蛋白酶。
Adv Exp Med Biol. 2011;712:49-61. doi: 10.1007/978-1-4419-8414-2_4.
2
The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin.刚地弓形虫的组织蛋白酶L（TgCPL）及其内源性大分子抑制剂弓形虫抑素。
Mol Biochem Parasitol. 2009 Mar;164(1):86-94. doi: 10.1016/j.molbiopara.2008.11.012. Epub 2008 Dec 6.
3
Toxoplasma gondii cathepsin proteases are undeveloped prominent vaccine antigens against toxoplasmosis.刚地弓形虫组织蛋白酶蛋白酶是未开发的针对弓形虫病的突出疫苗抗原。
BMC Infect Dis. 2013 May 7;13:207. doi: 10.1186/1471-2334-13-207.
4
A cathepsin C-like protease mediates the post-translation modification of secretory proteins for optimal invasion and egress.一种组织蛋白酶 C 样蛋白酶介导分泌蛋白的翻译后修饰，以实现最佳的入侵和逸出。
mBio. 2023 Aug 31;14(4):e0017423. doi: 10.1128/mbio.00174-23. Epub 2023 Jun 16.
5
Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.弓形虫组织蛋白酶L是入侵抑制化合物吗啉脲-亮氨酰-高苯基-乙烯基砜苯基的主要作用靶点。
J Biol Chem. 2009 Sep 25;284(39):26839-50. doi: 10.1074/jbc.M109.003780. Epub 2009 Jul 13.
6
Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii.组织蛋白酶C对于原生动物寄生虫刚地弓形虫的细胞内存活至关重要。
J Biol Chem. 2007 Feb 16;282(7):4994-5003. doi: 10.1074/jbc.M606764200. Epub 2006 Dec 12.
7
A cathepsin C-like protease post-translationally modifies secretory proteins for optimal invasion and egress.一种组织蛋白酶C样蛋白酶在翻译后修饰分泌蛋白，以实现最佳的入侵和逸出。
bioRxiv. 2023 Jan 22:2023.01.21.525043. doi: 10.1101/2023.01.21.525043.
8
Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.弓形虫中两种木瓜蛋白酶家族蛋白酶的非典型成熟过程。
J Biol Chem. 2013 Feb 1;288(5):3523-34. doi: 10.1074/jbc.M112.443697. Epub 2012 Dec 18.
9
Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella.艾美耳球虫蛋白酶，一种组织蛋白酶 B 样半胱氨酸蛋白酶，在艾美耳属寄生虫的孢子形成过程中表达。
PLoS One. 2012;7(3):e31914. doi: 10.1371/journal.pone.0031914. Epub 2012 Mar 22.
10
A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica.幼年侵袭性肝片吸虫表达了一组独特的组织蛋白酶。
Biochimie. 2008 Oct;90(10):1461-75. doi: 10.1016/j.biochi.2008.04.020. Epub 2008 Jun 5.
引用本文的文献
1
Transient Adaptation of to Exposure by Thiosemicarbazone Drugs That Target Ribosomal Proteins Is Associated with the Upregulated Expression of Tachyzoite Transmembrane Proteins and Transporters.硫代卡巴肼类药物靶向核糖体蛋白导致的 短暂适应与速殖子跨膜蛋白和转运体的上调表达有关。
Int J Mol Sci. 2024 Aug 21;25(16):9067. doi: 10.3390/ijms25169067.
2
infection: novel emerging therapeutic targets.感染：新出现的治疗靶点。
Expert Opin Ther Targets. 2023 Apr-May;27(4-5):293-304. doi: 10.1080/14728222.2023.2217353. Epub 2023 May 24.
3
The Toxoplasma plant-like vacuolar compartment (PLVAC).刚地弓形虫类植物液泡隔室（PLVAC）。
J Eukaryot Microbiol. 2022 Nov;69(6):e12951. doi: 10.1111/jeu.12951. Epub 2022 Oct 27.
4
Host-Parasite Interaction of Atlantic salmon () and the Ectoparasite in Amoebic Gill Disease.大西洋鲑鱼（ ）与粘孢子虫的寄生虫-宿主相互作用。
Front Immunol. 2021 May 31;12:672700. doi: 10.3389/fimmu.2021.672700. eCollection 2021.
5
Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion.组织蛋白酶 B 蛋白酶和天冬氨酸蛋白酶 1 对于内溶酶体蛋白消化不是必需的。
mSphere. 2020 Feb 12;5(1):e00869-19. doi: 10.1128/mSphere.00869-19.
6
Discovery and Optimization of Triazine Nitrile Inhibitors of Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.发现和优化三嗪腈类组织蛋白酶 L 抑制剂，用于治疗中枢神经系统慢性弓形体病的潜在疗法。
ACS Chem Neurosci. 2020 Aug 19;11(16):2450-2463. doi: 10.1021/acschemneuro.9b00674. Epub 2020 Feb 18.
7
An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion.疟原虫氯喹耐药转运蛋白（PfCRT）的同源物在维持刚地弓形虫内溶酶体系统的完整性方面发挥着关键作用，以促进宿主入侵。
PLoS Pathog. 2019 Jun 6;15(6):e1007775. doi: 10.1371/journal.ppat.1007775. eCollection 2019 Jun.
8
iTRAQ-Based Comparative Proteomic Analysis of Adult from Water Buffalo and Yellow Cattle.基于iTRAQ的水牛和黄牛成年个体比较蛋白质组学分析
Front Microbiol. 2018 Feb 6;9:99. doi: 10.3389/fmicb.2018.00099. eCollection 2018.
9
DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice.编码刚地弓形虫组织蛋白酶C 1的DNA疫苗可诱导小鼠对弓形虫病产生保护作用。
Korean J Parasitol. 2017 Oct;55(5):505-512. doi: 10.3347/kjp.2017.55.5.505. Epub 2017 Oct 31.
10
Protection via a ROM4 DNA vaccine and peptide against Toxoplasma gondii in BALB/c mice.通过ROM4 DNA疫苗和肽对BALB/c小鼠进行抗弓形虫保护。
BMC Infect Dis. 2017 Jan 11;17(1):59. doi: 10.1186/s12879-016-2104-z.
本文引用的文献
1
Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii.组织蛋白酶 L 占据空泡区，是刚地弓形虫内吞体/外排体系统中的一种蛋白成熟酶。
Mol Microbiol. 2010 Jun;76(6):1340-57. doi: 10.1111/j.1365-2958.2010.07181.x. Epub 2010 Apr 23.
2
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole.弓形虫中具有类似植物液泡组成和功能的新型细胞器的特征。
Mol Microbiol. 2010 Jun;76(6):1358-75. doi: 10.1111/j.1365-2958.2010.07165.x. Epub 2010 Apr 14.
3
MEROPS: the peptidase database.MEROPs：肽酶数据库。
Nucleic Acids Res. 2010 Jan;38(Database issue):D227-33. doi: 10.1093/nar/gkp971. Epub 2009 Nov 5.
4
Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells.蛋白酶激活受体信号传导对于非洲锥虫穿透人脑微血管内皮细胞是必需的。
PLoS Negl Trop Dis. 2009 Jul 21;3(7):e479. doi: 10.1371/journal.pntd.0000479.
5
Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.弓形虫组织蛋白酶L是入侵抑制化合物吗啉脲-亮氨酰-高苯基-乙烯基砜苯基的主要作用靶点。
J Biol Chem. 2009 Sep 25;284(39):26839-50. doi: 10.1074/jbc.M109.003780. Epub 2009 Jul 13.
6
Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80.在缺乏Ku80的弓形虫菌株中对内源基因进行标记。
Eukaryot Cell. 2009 Apr;8(4):530-9. doi: 10.1128/EC.00358-08. Epub 2009 Feb 13.
7
A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii.发动蛋白是刚地弓形虫分泌细胞器生物发生所必需的。
Curr Biol. 2009 Feb 24;19(4):277-86. doi: 10.1016/j.cub.2009.01.039. Epub 2009 Feb 12.
8
Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis.疟原虫胞质分裂的完成需要Rab11A控制内膜复合体的组装。
PLoS Pathog. 2009 Jan;5(1):e1000270. doi: 10.1371/journal.ppat.1000270. Epub 2009 Jan 23.
9
Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells.宿主内质网-吞噬泡相互作用为刚地弓形虫感染的树突状细胞中的抗原交叉呈递提供了一条进入途径。
J Exp Med. 2009 Feb 16;206(2):399-410. doi: 10.1084/jem.20082108. Epub 2009 Jan 19.
10
The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin.刚地弓形虫的组织蛋白酶L（TgCPL）及其内源性大分子抑制剂弓形虫抑素。
Mol Biochem Parasitol. 2009 Mar;164(1):86-94. doi: 10.1016/j.molbiopara.2008.11.012. Epub 2008 Dec 6.
Zotero 插件