去细胞神经同种异体移植物在周围神经再生中的应用：一项比较研究。
Acellular nerve allografts in peripheral nerve regeneration: a comparative study.
机构信息
Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, Campus Box 8238, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
出版信息
Muscle Nerve. 2011 Aug;44(2):221-34. doi: 10.1002/mus.22033. Epub 2011 Jun 9.
INTRODUCTION
Processed nerve allografts offer a promising alternative to nerve autografts in the surgical management of peripheral nerve injuries where short deficits exist.
METHODS
Three established models of acellular nerve allograft (cold-preserved, detergent-processed, and AxoGen-processed nerve allografts) were compared with nerve isografts and silicone nerve guidance conduits in a 14-mm rat sciatic nerve defect.
RESULTS
All acellular nerve grafts were superior to silicone nerve conduits in support of nerve regeneration. Detergent-processed allografts were similar to isografts at 6 weeks postoperatively, whereas AxoGen-processed and cold-preserved allografts supported significantly fewer regenerating nerve fibers. Measurement of muscle force confirmed that detergent-processed allografts promoted isograft-equivalent levels of motor recovery 16 weeks postoperatively. All acellular allografts promoted greater amounts of motor recovery compared with silicone conduits.
CONCLUSION
These findings provide evidence that differential processing for removal of cellular constituents in preparing acellular nerve allografts affects recovery in vivo.
简介
在存在短神经缺损的周围神经损伤的外科治疗中，处理过的同种异体神经移植物为神经自体移植物提供了一种很有前途的替代方法。
方法
在 14mm 大鼠坐骨神经缺损模型中，将三种已建立的去细胞同种异体神经移植物（冷保存、去污剂处理和 AxoGen 处理的同种异体神经移植物）与神经同种异体移植物和硅胶神经引导管进行比较。
结果
所有去细胞同种异体神经移植物在支持神经再生方面均优于硅胶神经导管。去污剂处理的同种异体移植物在术后 6 周时与同种异体移植物相似，而 AxoGen 处理和冷保存的同种异体移植物支持的再生神经纤维明显较少。肌肉力量的测量结果证实，去污剂处理的同种异体移植物在术后 16 周时促进了与同种异体移植物相当的运动功能恢复。与硅胶导管相比，所有去细胞同种异体移植物均促进了更大程度的运动功能恢复。
结论
这些发现提供了证据表明，在制备去细胞同种异体神经移植物时，去除细胞成分的差异处理会影响体内的恢复。
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