Miskulin Maja, Miskulin Ivan, Milas Josip, Antolović-Pozgain Arlen, Rudan Stjepan, Vuksić Melita
Institute of Public Health for the Osijek-Baranya County, Osijek, Croatia.
Coll Antropol. 2011 Mar;35(1):9-14.
The aim of the study was to establish the seroprevalence of herpes simplex virus type 2 (HSV-2) among sexually active adults from East Croatia and to evaluate its correlates with demographic and behavioural risk factors. This cross-sectional study was conducted from the 1st June until the 30th September 2005 at the Department of Transfusion Medicine, Osijek University Hospital Center. The study included 423 blood donors composed of 366 (86.5%) men and 57 (13.5%) women. Demographic data and data on the risky sexual behaviour during the lifetime were collected with usage of an anonymous questionnaire consisting of 15 questions. Western blot testing revealed that 3.3% (14/423) subjects were positive for the presence of IgG antibodies to herpes simplex virus 2, i.e. 10 (2.7%) men and 4 (7.0%) women. A higher HSV-2 seroprevalence was associated with female sex, older age, marital status (with single subjects been under the greater risk), irregular condom use on sexual intercourses with new partners and with higher number (five or more) of sexual partners during lifetime. Among determined risk factors in the study population, only the connection between the HSV-2 positivity and the older age was statistically significant. The study has showed that the demographic rather than the behavioural risk factors are associated with higher prevalence of HSV-2 antibodies in the observed population.
该研究的目的是确定东克罗地亚性活跃成年人中2型单纯疱疹病毒（HSV-2）的血清流行率，并评估其与人口统计学和行为风险因素的相关性。这项横断面研究于2005年6月1日至9月30日在奥西耶克大学医院中心输血医学科进行。该研究纳入了423名献血者，其中366名（86.5%）为男性，57名（13.5%）为女性。使用一份由15个问题组成的匿名问卷收集了人口统计学数据和一生中危险性行为的数据。蛋白质印迹检测显示，3.3%（14/423）的受试者单纯疱疹病毒2型IgG抗体呈阳性，即10名（2.7%）男性和4名（7.0%）女性。较高的HSV-2血清流行率与女性、年龄较大、婚姻状况（单身受试者风险更大）、与新伴侣性交时不规律使用避孕套以及一生中性伴侣数量较多（五个或更多）有关。在研究人群中确定的风险因素中，只有HSV-2阳性与年龄较大之间的关联具有统计学意义。该研究表明，在观察到的人群中，人口统计学而非行为风险因素与HSV-2抗体的较高流行率相关。
